ORAgene.
A full saliva sample, DNA locked in.
ORAgene is DNA Genotek’s flagship spit device: the patient gives a full saliva sample through a funnel, and closing the lid releases a stabilising buffer that preserves high-molecular-weight DNA at the point of collection (ambient-stable, ready to be returned to an accredited lab). Curated and supplied on the Humans Nexus platform; DNA Genotek is the manufacturer.
ORAgene saliva self-collection.
ORAgene is a saliva microsampling device from DNA Genotek built for self-collection: the patient spits into a funnel on top of the tube until a full sample is reached, then closes the lid, which releases a stabilising buffer that mixes with the saliva and preserves the DNA at the moment of collection. Per the manufacturer, the larger sample yields high-molecular-weight DNA suited to whole-genome sequencing, genotyping and long-term biobanking, and the ambient-stable tube travels at room temperature and reaches the laboratory intact. Humans Nexus curates and supplies the device on its platform and assembles the clinical-grade kit around it; DNA Genotek is the legal manufacturer.
A generous sample,
DNA for the long run.
Saliva is a non-invasive way to reach germline DNA, but oral fluid degrades quickly once collected and yield varies from person to person. ORAgene is designed by the manufacturer to capture a larger volume and stabilise it at collection, so an ambient-stable tube can travel by ordinary tracked post and still deliver the high-molecular-weight DNA that sequencing and biobanking need.
Which saliva device?
Two DNA Genotek saliva devices, one decision: how the sample is given. ORAgene takes a full spit through a funnel, the higher-yield route for adult self-collection. ORAcollect uses a sponge in the cap to collect or swab, the gentler option for children, infants and anyone who can’t spit on cue.
| ORAgene | ORAcollect | |
|---|---|---|
| Collection | Spit into the funnel | Sponge in the cap, collect or swab |
| Best suited to | Adult self-collection | Children, infants & assisted collection |
| Typical volume | Larger, a full saliva sample | Smaller, targeted |
| DNA yield | High-molecular-weight DNA, sequencing & biobanking | Ready DNA for routine molecular tests |
| Stabilisation | Liquid buffer, ambient 1 yr+ | Liquid buffer, ambient 1 yr+ |
| Lab handling | Standard robotics, no tip-cutting | Standard robotics, no tip-cutting |
Both share DNA Genotek’s liquid stabilisation (a bacteriostatic buffer that holds DNA at room temperature for a year or more) and both run on standard laboratory robotics without tip-cutting. The right device depends on who collects and what the assay needs; method validation runs per assay before patient-facing reporting. See ORAcollect →
Spit. Stabilise. Return.
The patient spits into the funnel at home until a full saliva sample is collected (no clinic, no clinician).
Closing the lid releases the stabilising buffer, which mixes with the saliva and locks the DNA at ambient temperature.
Ships by tracked return with no cold chain; the lab processes the stabilised sample.
Assembled into a kit.
The ORAgene device is curated onto the platform and assembled into a regulated Humans Nexus collection kit (device, stabilising buffer, tamper-evident return packaging and app-guided instructions, under its own UDI).
For genetics and biobanking.
Good to know.
What does ORAgene collect?
Saliva. It is a self-collection device: the patient spits into a funnel to give a full saliva sample, which is stabilised at collection for high-molecular-weight, oral-fluid DNA.
How is it different from ORAcollect?
ORAgene is a spit device for adult self-collection and a larger, higher-yield sample; ORAcollect uses a sponge in the cap to collect or swab, which suits children, infants and assisted collection. Both are DNA Genotek saliva devices sharing the same liquid stabilisation.
Does it need cold chain?
No. Per the manufacturer, the device stabilises the sample at collection, so the ambient-stable tube is designed to ship at room temperature by standard tracked return.
Who is the manufacturer?
DNA Genotek makes the device. Humans Nexus curates and supplies it on the platform and assembles the clinical-grade kit around it. Method validation runs per assay before patient-facing reporting.
The research library.
No papers match these filters.
External links open an open-access full text where one exists, otherwise the publisher or PubMed record. These citations describe the published evidence for the collection formats and devices (not claims about specific Humans Nexus assays, which are validated per analyte and per laboratory).
Put self-collected saliva on your platform.
Talk to us about ORAgene for your programme.