Urine microsampling,
liquid and dried.

Urine, self-collected at home across the whole ladder: a standardised first-void fraction with Colli-Pee for HPV and sexually transmitted infections, dried urine for economical hormone-metabolite panels, and VAMS by Neoteryx Mitra where a fixed volume and room-temperature stability matter, for hormone, steroid, drug and renal markers, returned to an accredited laboratory under chain of custody.

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Colli-Pee first-void urine collection device by DNA Genotek, on the Humans Nexus microsampling platform
Defined

What is urine
microsampling?

Urine microsampling is the collection of a defined urine sample by the patient, at home or at the point of care, and its return to an accredited laboratory under documented chain of custody: a standardised first-void fraction for molecular targets, a first-morning or timed liquid collection, or a dried format, a spot on a card or a fixed volume on a VAMS tip, that ships at ambient temperature. It is the microsampling model applied to urine: patient-collected, small-format, tracked through the platform. The industry also calls it urine self-sampling, home urine collection or, for HPV and STI work, first-void urine self-collection.

The formats

Three ways to collect urine.

Conventional urine depends on voided volume, cold-chain shipping and preservatives. Dried formats remove most of that burden by absorbing a small aliquot that dries and ships ambient. Of the dried options, VAMS is the one that also fixes the volume.

Liquid urineDried urine spotVAMS
FormatVoided or timed collectionDrops dried on a cardFixed volume on a tip
Volume controlFull sampleUncontrolled spotFixed at the tip, viscosity-independent
Cold chainRefrigerate or preserveAmbientAmbient
Ambient stabilityLimited, degrades in transitGoodBest, outperforms DUS on long storage
Best-established useFirst-void molecular, HPV and STI; high-volume and biobankEconomical dried panelsVolumetric accuracy & stability
Device on the platformColli-Pee for first-void; a cup for timed collectionsFilter-paper cardNeoteryx Mitra tip

Drying urine at the point of collection halts the bacterial and thermal degradation that affects wet urine in transit. In a direct side-by-side on the same urine, VAMS held long-term room-temperature stability better than a dried urine spot, recovering more than 82% of anabolic steroids after a year against 70% from the spot, which is why we make VAMS the volumetric dried choice.

Liquid, done right

First-void, by Colli-Pee.

Not all liquid urine is equal. For urogenital molecular targets, high-risk HPV, chlamydia, gonorrhoea, Mycoplasma genitalium and related biomarkers, the first-void fraction, the first millilitres of the stream, concentrates the cells and analytes that a random midstream sample dilutes. Colli-Pee captures a standardised, defined volume of that fraction into a tube that can be prefilled with a conservation medium, which is what makes liquid urine a reproducible molecular matrix at home. In the VALHUDES study, high-risk HPV testing on Colli-Pee first-void urine was as sensitive for high-grade cervical precancer as clinician-taken cervical samples, relative sensitivity 0.95 and relative specificity 1.03, and at-home Colli-Pee collection agreed with clinic urine for chlamydia, gonorrhoea and Mycoplasma genitalium at kappa 0.75, 0.87 and 0.85. Colli-Pee is CE-marked, CE-IVD in its stabilised configuration; DNA Genotek is the manufacturer.

Colli-Pee →   All DNA Genotek devices on the platform →

Our volumetric choice

VAMS, by Neoteryx.

After blood, urine is the most applied matrix for volumetric absorptive microsampling in forensic work. The Neoteryx Mitra tip wicks a fixed volume regardless of the sample’s viscosity, dries, and ships ambient, giving a quantitatively consistent dried urine sample without a cold chain: on the same urine, a Mitra tip kept more than 82% of anabolic steroids after a year at room temperature against 70% for a dried spot, and a 237-substance, 11-class anti-doping screen now runs on Mitra tips as well as on cards. Humans Nexus curates and supplies the device on the platform and assembles the regulated kit around it; Neoteryx is the manufacturer.

Steroid & hormone profilesAnabolic-androgenic steroids and reproductive-hormone metabolites, quantified from a fixed dried volume.
Drug & adherence monitoringExposure and compliance testing, validated for cold-chain-free dried urine quantitation.
Metabolomics & screeningBroad drug and metabolite screening where dried urine matches liquid across most analytes.

Neoteryx Mitra →

Urine VAMS is positioned for hormone and steroid panels, drug/adherence and metabolite work, not for immunosuppressant therapeutic drug monitoring, which is a blood assay. Suitability is established per analyte through method validation.

What it measures

A validated panel.

Molecular, first-voidHigh-risk HPV DNA, chlamydia, gonorrhoea, Mycoplasma genitalium and HPV antibodies from a standardised first-void fraction
Hormone metabolitesEstrogen, progesterone and cortisol metabolites: dried-urine profiling across a cycle, four spots standing in for a 24-hour collection
Steroids & anti-dopingAnabolic-androgenic steroid panels and an 11-class prohibited-substance screen from dried urine
Renal & metabolicAlbumin-to-creatinine ratio and hydration markers on liquid urine; organic acids on dried spots
Liquid vs dried

An honest trade-off.

Dried is not universally better; it is a logistics choice. Dried VAMS and DUS win on transport, room-temperature storage, biohazard handling and volumetric consistency; they suit hormone, steroid, drug and metabolite work collected from home. Liquid urine keeps an edge where you need large volumes, ultra-low-abundance analytes, or an established frozen-biobank workflow, many clinical-chemistry parameters remain valid for years frozen without preservative. We offer the whole ladder and match the format to the analyte, not the other way round.

How it works

From collection to lab.

01Collect

A first-void fraction into the Colli-Pee, a first-morning or timed sample into a preserved container, a few drops onto a dried-urine card, or a fixed volume onto a Mitra tip, matched to the panel.

02Seal & return

Sealed and ID-matched, the kit returns by tracked courier: dried and VAMS formats at ambient temperature, preserved first-void urine by regular post as validated, and controlled-temperature transport only where a liquid panel requires it.

03Result

The laboratory accessions the sample under the same chain of custody, and the result returns through the platform into your system.

The evidence

What the record shows.

Each figure below belongs to the study that produced it. A device is named only where the paper’s abstract names it.

HPV screening on first-void urineIn the VALHUDES study, high-risk HPV testing on Colli-Pee first-void urine reached a relative sensitivity of 0.95 and a relative specificity of 1.03 for high-grade cervical precancer against clinician-taken cervical samples (Gynecologic Oncology, 2021).
The same result, a second assay500 women, a different HPV assay: first-void urine matched cervical samples, sensitivity ratio 0.95 and specificity ratio 1.03, where vaginal self-samples lost specificity (Journal of Medical Virology, 2024).
STI testing from home, by post473 home Colli-Pee samples from 213 men, sent by regular post, agreed with clinic urine at kappa 0.75 for chlamydia, 0.87 for gonorrhoea and 0.85 for Mycoplasma genitalium; home collection found eleven infections the clinic sample missed and missed three (BMJ Open, 2019).
Robust to over-collection27,042 first-void specimens, 1,611 of them overfilled to a median 60 mL: gonorrhoea positivity 3.23% against 2.66% and chlamydia 2.86% against 2.92%, neither difference significant (Microbiology Spectrum, 2025).
Four dried spots for a 24-hour collectionFour dried spots across a day against a 24-hour liquid collection, 17 reproductive hormones and metabolites, intraclass correlations above 0.90 (BMC Chemistry, 2021).
VAMS against the dried spotDried spot against VAMS on the same urine for unconjugated anabolic steroids, quantification limits at or below 1.5 ng/mL; after a year at room temperature VAMS recovered more than 82% and the spot 70% (Molecules, 2020).

Method validation runs per analyte and per format before a result is reported. The full reading list follows below.

Clinical-grade by design

Sealed. Tracked.
Ambient-stable.

Preservative-stabilised liquid collection, dried-urine cards and VAMS tips are matched to each panel’s validated requirements, sealed and tracked end to end. Dried and volumetric formats ship ambient; liquid uses controlled-temperature transport where the panel requires it. Every kit is ID-matched and sealed, its UDI bound to a chain of custody at activation and tracked by courier scan to accessioning. Method validation runs into ISO 15189-accredited laboratories before patient-facing reporting.

The kit

What’s in the box.

Urine | Cell

  • Colli-Pee first-void collector, or a preserved cup for timed collections
  • Dried-urine card or Neoteryx Mitra tips, matched to the panel
  • ID-matched, tamper-evident seal
  • Tracked return packaging, ambient for dried and preserved formats
  • Guided collection in Flow, step by step
All kits →
Who it’s for

Whoever runs the test.

LaboratoriesAdd first-void HPV and STI self-sampling, and dried-urine hormone, steroid and metabolite profiling
Pharma & CROMetabolite PK and adherence off-site
Digital healthFertility and hormone tracking, at home
InsurersRenal and metabolic markers at scale

Infrastructure for healthcare and life sciences. Our partners reach the patient, and we never sell directly.

Good to know.

Why dried or volumetric urine instead of liquid?

Dried formats ship at ambient temperature without refrigeration and halt the degradation that affects wet urine in transit. VAMS adds a fixed, viscosity-independent volume for quantitation. Liquid still suits high-volume, ultra-low-abundance or established frozen-biobank work; it is a trade-off matched to the analyte.

Why VAMS rather than a dried urine spot?

Both dry and ship ambient, but VAMS fixes the collected volume at the tip and, in a direct comparison on the same urine, held long-term room-temperature stability better than a dried urine spot, more than 82% recovery of anabolic steroids after a year against 70%, so it is our volumetric dried choice where accuracy and storage matter.

What can urine microsampling measure?

High-risk HPV, chlamydia, gonorrhoea and Mycoplasma genitalium on a standardised first-void fraction; hormone and steroid metabolites, reproductive markers, drug and adherence testing and multi-class doping panels on dried urine; renal and metabolic markers such as albumin-to-creatinine ratio on liquid urine. Not immunosuppressant TDM, which is a blood assay.

Which urine collection devices do you use?

Colli-Pee by DNA Genotek for a standardised first-void fraction, Neoteryx Mitra tips for volumetric dried urine, and filter-paper cards for dried urine spots, each assembled into the regulated kit with the preservative or medium the panel needs.

Is first-void urine as good as a cervical sample for HPV screening?

In the VALHUDES study, high-risk HPV testing on Colli-Pee first-void urine was as sensitive for high-grade cervical precancer as clinician-taken cervical samples, relative sensitivity 0.95 and relative specificity 1.03, with a validated assay and cut-off. It is the route for women who do not attend for a cervical sample.

Can STI testing be done on urine collected at home?

Yes. In 213 men sending 473 Colli-Pee samples by regular post, home first-void urine agreed with clinic urine for chlamydia, gonorrhoea and Mycoplasma genitalium at kappa 0.75, 0.87 and 0.85.

Does the collected volume matter?

Colli-Pee fixes the first-void volume, which is the point. Across 27,042 first-void specimens, over-collection did not change chlamydia or gonorrhoea positivity, and in Colli-Pee tubes of 4, 10 and 20 mL the DNA extraction method mattered more than the volume: capture the first fraction, then standardise the processing.

Does it need a cold chain?

Dried and VAMS formats do not; preserved first-void urine travels by regular post as validated; other liquid collections use preservatives and controlled-temperature transport where the panel requires it.

OpenSampling Library by Humans Nexus

Library Urine microsampling

Every paper read and summarised in our own words, each on a page of its own in the OpenSampling Library.

Newest

  1. Diagnostic Performance of HPV Testing Using Self-Collected Urine and Vaginal Samples for Detecting Cervical Precancer or Worse: A Meta-Analysis

    The journal of obstetrics and gynaecology research · 2026 · Paywalled

    This meta-analysis found that HPV testing using self-collected vaginal and urine samples showed sensitivities of 88.6% and 81% for detecting cervical precancer. Using a standardised device for first-void urine increased sensitivity to 86.6%, supporting decentralised

    Read in the Library

  2. Evaluating DNA methylation markers and extended HPV genotyping in first-void urine for detecting high-grade cervical lesions in HPV-positive women: a cross-sectional study

    BMC medicine · 2026 · Open access

    DNA methylation markers in first-void urine effectively detect high-grade cervical lesions in HPV-positive women, with results similar to clinician-collected samples in those over 30. This enables reliable cervical cancer screening using self-collected urine,

    Read in the Library

  3. Comparative efficacy, feasibility and acceptability of HPV DNA testing on first-void urine versus self-collected vaginal samples: a real-world study in a resource-limited setting

    BMJ global health · 2026 · Open access

    A study of 2500 women found 99.0% agreement between first-void urine and vaginal self-sampling for HPV detection using Cobas4800, with 98.1% of participants preferring urine. Although conducted in a resource-limited setting which may limit generalisability, these

    Read in the Library

  4. Comparison of self-collected vaginal swabs and first-void urine for detection of human papillomavirus in sexually active girls and women in three South Asian countries

    PloS one · 2026 · Open access

    This study found that self-collected vaginal swabs and first-void urine yielded comparable detection rates for vaccine-targeted high-risk HPV types, supporting the use of both patient-centric methods for decentralised surveillance. Vaginal swabs showed higher sensitivity for non-vaccine

    Read in the Library

  5. HPV detection in first void urine and cervicovaginal samples: comparative study and analysis of associated factors in women from tunja, colombia

    Preventive medicine reports · 2026 · Open access

    A comparison of human papillomavirus detection in first-void urine and cervicovaginal samples from Colombian women showed moderate prevalence but weak concordance between the two methods. Although urine-based screening offers a non-invasive alternative, its limited diagnostic performance in this

    Read in the Library

  6. Comparative performance of first-void urine and self-collected vaginal swabs against clinician-collected cervical samples using 2 HPV real-time assays in Indian women

    Journal of gynecologic oncology · 2026 · Paywalled

    First-void urine and self-collected vaginal swabs showed similar sensitivity and specificity to clinician-collected cervical samples for high-risk HPV detection across two real-time PCR assays, supporting their use as decentralised,

    Read in the Library

All 488 in the OpenSampling Library

First-void urine

  1. Diagnostic Performance of HPV Testing Using Self-Collected Urine and Vaginal Samples for Detecting Cervical Precancer or Worse: A Meta-Analysis

    The journal of obstetrics and gynaecology research · 2026 · Paywalled

    This meta-analysis found that HPV testing using self-collected vaginal and urine samples showed sensitivities of 88.6% and 81% for detecting cervical precancer. Using a standardised device for first-void urine increased sensitivity to 86.6%, supporting decentralised

    Read in the Library

  2. Evaluating DNA methylation markers and extended HPV genotyping in first-void urine for detecting high-grade cervical lesions in HPV-positive women: a cross-sectional study

    BMC medicine · 2026 · Open access

    DNA methylation markers in first-void urine effectively detect high-grade cervical lesions in HPV-positive women, with results similar to clinician-collected samples in those over 30. This enables reliable cervical cancer screening using self-collected urine,

    Read in the Library

  3. Comparative efficacy, feasibility and acceptability of HPV DNA testing on first-void urine versus self-collected vaginal samples: a real-world study in a resource-limited setting

    BMJ global health · 2026 · Open access

    A study of 2500 women found 99.0% agreement between first-void urine and vaginal self-sampling for HPV detection using Cobas4800, with 98.1% of participants preferring urine. Although conducted in a resource-limited setting which may limit generalisability, these

    Read in the Library

  4. Comparison of self-collected vaginal swabs and first-void urine for detection of human papillomavirus in sexually active girls and women in three South Asian countries

    PloS one · 2026 · Open access

    This study found that self-collected vaginal swabs and first-void urine yielded comparable detection rates for vaccine-targeted high-risk HPV types, supporting the use of both patient-centric methods for decentralised surveillance. Vaginal swabs showed higher sensitivity for non-vaccine

    Read in the Library

  5. HPV detection in first void urine and cervicovaginal samples: comparative study and analysis of associated factors in women from tunja, colombia

    Preventive medicine reports · 2026 · Open access

    A comparison of human papillomavirus detection in first-void urine and cervicovaginal samples from Colombian women showed moderate prevalence but weak concordance between the two methods. Although urine-based screening offers a non-invasive alternative, its limited diagnostic performance in this

    Read in the Library

  6. Comparative performance of first-void urine and self-collected vaginal swabs against clinician-collected cervical samples using 2 HPV real-time assays in Indian women

    Journal of gynecologic oncology · 2026 · Paywalled

    First-void urine and self-collected vaginal swabs showed similar sensitivity and specificity to clinician-collected cervical samples for high-risk HPV detection across two real-time PCR assays, supporting their use as decentralised,

    Read in the Library

All 234 in the OpenSampling Library

Liquid

  1. The potential use of midstream urine samples for diagnosing Chlamydia/Gonorrhoea NAAT in male and female patients, and the pre-analytical storage conditions in neat urine specimens

    The new microbiologica · 2026 · Paywalled

    Midstream urine self-collection demonstrated adequate sensitivity for Chlamydia trachomatis screening in asymptomatic patients, although it was less sensitive than vaginal swabs in women, and the study confirmed

    Read in the Library

  2. Agreement between INDICAID™ HPV (human papillomavirus) Urine Test and BD Onclarity™ HPV Assay in detection of high-risk HPV in self-collected urine samples

    Journal of gynecologic oncology · 2026 · Paywalled

    This study found strong agreement between self-collected urine samples tested with the INDICAID HPV assay and clinician-collected swabs tested with the BD Onclarity assay for detecting high-risk HPV. The results suggest that urine-based self-collection offers a reliable alternative for

    Read in the Library

  3. Integrating Microsampling in Human Biomonitoring: Methodologies, Regulatory Frameworks, and Case Study Insights

    Critical reviews in analytical chemistry · 2026 · Paywalled

    This review establishes that microsampling across blood, saliva, urine and stool matrices offers validated workflows and regulatory recognition for human biomonitoring comparable to conventional methods. It finds that these decentralised approaches enhance participant

    Read in the Library

  4. A Noninvasive Method for Dynamic Ovulation Monitoring Based on Memristor

    ACS omega · 2026 · Open access

    This study demonstrates that a memristor sensor can identify distinct electrical signatures in saliva and urine corresponding to different ovulation phases,

    Read in the Library

  5. Integrated Methylation and Copy Number Analysis for Noninvasive Bladder Cancer Detection in Urine

    JCO precision oncology · 2026 · Paywalled

    The authors developed an integrated sequencing workflow that simultaneously profiles copy number aberrations and a three-gene methylation panel from home-collected urine cell-free DNA, achieving high diagnostic accuracy for both primary and recurrent bladder cancer in a cohort of 89

    Read in the Library

  6. Application of PathoChip to urine-derived nucleic acids for broad microbial profiling in men with suspected prostate cancer: setup of a methodological workflow and pilot feasibility study

    The journal of liquid biopsy · 2026 · Paywalled

    An eight-millilitre sample of first-morning urine self-collected without prostatic massage yields reproducible microbial profiles using PathoChip microarray. The workflow identified Streptococcaceae enrichment in higher-grade prostate cancer, supporting

    Read in the Library

All 62 in the OpenSampling Library

Dried

  1. Volumetric absorptive microsampling device for forensic Toxicologic screening: A case report as proof-of-concept

    Forensic science international · 2026 · Paywalled

    A post-mortem case study found that Mitra microsampling devices achieved comparable qualitative toxicological detection to conventional methods across blood, urine, bile, and vitreous humour, successfully identifying methamphetamine, opioids, and alpha-PHP. Whilst limited to a single case, this shows that microsampling is a viable

    Read in the Library

  2. Evaluation of the Quality and Suitability of Self-Collected Vaginal and Urine Samples for Human Papillomavirus Testing: A Prospective Matched Study

    BJOG · 2026 · Open access

    For decentralised testing, a study found dry vaginal self-samples using Copan FLOQSwabs stored up to two weeks at room temperature maintain DNA quality. However, first-void urine collected with the Colli-Pee device may be less sensitive for HPV detection,

    Read in the Library

  3. Prevalence of chlamydial, gonococcal and syphilis positivity by anatomical site and sex via self-collected biospecimens using at-home testing kits among a large and diverse cohort of men and women enrolled in the MACS/WIHS Combined Cohort Study (MWCCS) in the USA

    Sexually transmitted infections · 2026 · Paywalled

    The study found that self-collection of dried blood spots and other samples using at-home kits was a useful and cost-effective method for screening a large cohort for sexually transmitted infections outside a clinic. This demonstrates the feasibility of decentralised,

    Read in the Library

  4. Development and evaluation of dried urine strip for genital chlamydia and gonorrhea testing

    Journal of clinical microbiology · 2026 · Open access

    Dried urine strips demonstrated high diagnostic accuracy and stability for chlamydia and gonorrhea detection compared to standard urine samples. This method supports decentralised screening by allowing self-collection

    Read in the Library

  5. Serial Dried Blood Spot C-Peptide Sampling, but Not Urine C-Peptide-to-Creatinine Ratio, Detects Early Preservation of β-Cell Function in New-Onset Type 1 Diabetes: Experience From the USTEKID Trial

    Diabetes care · 2026 · Paywalled

    Frequent dried blood spot sampling detected early changes in beta-cell function more effectively than mixed-meal tolerance tests or urine ratios, supporting its

    Read in the Library

  6. Comprehensive at-home sexually transmitted and blood borne infection (STBBI) testing program: A pilot study

    International journal of STD & AIDS · 2026 · Open access

    This pilot study demonstrated that a fully remote web-based testing programme for sexually transmitted and blood-borne infections was feasible and acceptable overall, although participants

    Read in the Library

All 55 in the OpenSampling Library

VAMS

  1. Volumetric absorptive microsampling device for forensic Toxicologic screening: A case report as proof-of-concept

    Forensic science international · 2026 · Paywalled

    A post-mortem case study found that Mitra microsampling devices achieved comparable qualitative toxicological detection to conventional methods across blood, urine, bile, and vitreous humour, successfully identifying methamphetamine, opioids, and alpha-PHP. Whilst limited to a single case, this shows that microsampling is a viable

    Read in the Library

  2. Evaluation of oral fluid microsampling as a urine surrogate matrix in substance use disorder care: clinical applicability and analytical performance

    Clinical toxicology · 2026 · Paywalled

    The study found that oral fluid microsampling using VAMS has high patient acceptability, 90% vs 28% for urine, and over 88% agreement with urine toxicology screening, making it a practical alternative

    Read in the Library

  3. Mass Spectrometry-Based Anti-Doping Analysis: A Critical Review of Emerging Analytical and Sample Pretreatment Strategies

    Critical reviews in analytical chemistry · 2026 · Paywalled

    This review highlights that microsampling techniques such as dried blood spots and volumetric absorptive microsampling offer superior alternatives to traditional sampling for the mass spectrometry detection of prohibited substances in anti-doping analysis. It provides guidance on selecting appropriate analytical methods and sample

    Read in the Library

  4. LC-HRMS screening for 11 classes of prohibited substances in dried urine spots for doping control

    Analytical and Bioanalytical Chemistry · 2025 · Paywalled

    A multi-targeted procedure covered 237 prohibited substances across 11 WADA classes in dried urine spots, with

    Read in the Library

  5. Derivation of Human Toxicokinetic Parameters and Chemical-Specific Adjustment Factor of Citrinin Through a Human Intervention Trial and Hierarchical Bayesian Population Modeling

    Toxins · 2025 · Open access

    Researchers validated a UHPLC-MS/MS assay for citrinin in capillary blood collected with Neoteryx Mitra VAMS devices, plus feces and urine, achieving quantification limits of 0.05 ng/mL. The study derived human toxicokinetic parameters from 48-hour sample collection after a single oral

    Read in the Library

  6. Volumetric Absorptive Microsampling in Toxicology

    Toxics · 2024 · Open access

    Confirms urine is the second-most-applied VAMS matrix in forensics, collecting a consistent volume regardless of

    Read in the Library

All 22 in the OpenSampling Library

These citations describe the published evidence for the collection formats and devices, not claims about specific Humans Nexus assays, which are validated per analyte and per laboratory.

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Talk to us about adding liquid, dried and volumetric urine collection to your programme.

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