Neoteryx Mitra.
Exact volume, single touch.

Neoteryx Mitra captures a fixed, precise volume of capillary blood on a tip, a widely used device for quantitative dried-blood microsampling. Curated and supplied on the Humans Nexus platform; Neoteryx is the manufacturer.

Touch the drop. The tip fills itself.
The device

A fixed volume,
on a tip.

A Neoteryx Mitra volumetric absorptive microsampling device
The tip absorbs a fixed volume, which is what makes the sample quantitative.
A capillary blood sample being collected onto a Mitra microsampling tip from a fingertip
Collected from a fingertip, by the patient, without a tube or a centrifuge.
A Mitra microsampling kit being used away from a clinical setting
Dried on the tip, it travels at ambient temperature (no cold chain to hold).

The Mitra device uses VAMS, volumetric absorptive microsampling. Touch its absorbent tip to a drop of blood on a fingertip and it wicks a fixed volume in seconds (10, 20 or 30&thinsp);µL, the same every time, whatever the hematocrit. You know it’s full when the tip turns fully red; the manufacturer specifies volumetric precision within about 5% (RSD ≤ 5%). The tip then dries, ships at ambient temperature with no cold chain, and needs no centrifugation before the laboratory elutes it and runs the assay. Humans Nexus curates and supplies the device on its platform; Neoteryx is the legal manufacturer.

Why it matters

Where the spot
falls short.

A traditional dried blood spot varies with volume and with hematocrit, which limits quantitation. VAMS captures a fixed volume on each tip, which the manufacturer designs for the reproducibility quantitative assays demand (therapeutic drug monitoring, LC-MS/MS small molecules, and biomarker panels transferred from venous methods).

Fixed volumeA known 10, 20 or 30 µL on every tip: within about 5% (RSD ≤ 5%), per the manufacturer.
Hematocrit-tolerantVAMS is designed to reduce the hematocrit-related volume bias seen with classic dried blood spots.
Ambient shippingThe dried tip is stable at room temperature and ships with no cold chain.
How it works

Touch. Dry. Return.

01Touch

Touch the tip to a fingertip drop; it wicks a fixed 10–30 µL in seconds and turns fully red when it’s done.

02Dry

The tip dries on its station, stable at ambient temperature.

03Return

Ships by tracked return with no cold chain; the lab elutes and runs the validated assay.

Two tips. One clean click open.
On the platform

Assembled into a kit.

Mitra is curated onto the platform and assembled into a regulated Humans Nexus collection kit (device, safety lancet, drying station, ambient-stable return packaging and instructions, under its own UDI).

The deviceNeoteryx Mitra VAMS tips at the fixed volume the programme requires.
The consumablesSafety lancet, drying station and ambient-stable, tamper-evident return packaging.
The guidanceApp-guided instructions for a clean fixed-volume collection.

See the kits →

A field team collecting a Mitra capillary microsample from a fingertip on a rocky mountainside
A lab-grade sample, collected anywhere.
Who it’s for

For quantitative work.

LaboratoriesA quantitative dried-blood format
Pharma & CRODecentralised trials and TDM
Digital healthPrecise home blood in-app
InsurersAccurate biomarker underwriting

Good to know.

How much blood does it take?

A fixed 10, 20 or 30 µL per tip, chosen for the assay (a fraction of a venous tube, from a single finger-prick). The tip absorbs the same volume every time (the manufacturer specifies RSD ≤ 5%), and it turns fully red when it is full, which is what makes the dried sample quantitative.

How is Mitra different from a dried blood spot?

Mitra absorbs a fixed, known volume per tip, which the manufacturer designs to reduce the volume and hematocrit variability that limit traditional dried blood spots, so quantitative assays are more reliable.

What is VAMS best for?

Quantitative work: therapeutic drug monitoring, LC-MS/MS small-molecule assays, and biomarker panels transferred from venous methods. VAMS is widely used in TDM and PK research.

Does it need refrigeration?

No (the dried tip is stable at ambient temperature and ships by standard tracked return, with no cold chain).

Who is the manufacturer?

Neoteryx makes the Mitra device. Humans Nexus curates and supplies it on the platform and assembles the regulated kit around it. Method validation runs per assay before patient-facing reporting.

The evidence

The complete VAMS evidence base.

Peer-reviewed evidence for volumetric absorptive microsampling (the Mitra format, across both blood and urine) aggregated here and organised by where it is used: immunosuppressant, biologic, oncology and antimicrobial drug monitoring; biomarkers, vitamins and omics; infectious-disease serology; urine steroids and toxicology; and the haematocrit question the format was built to answer. Links open an open-access full text where one exists. This is evidence for the format, not a claim about any specific Humans Nexus assay.

21 papers

Sample type

Collection format

Device

Topic

Access

Clinical Validation of Venetoclax Volumetric Microsampling in Leukemia, with Whole-Blood-to-Plasma Conversion and Self-Microsampling FeasibilityLevens et al. · Clinical Pharmacokinetics · 2026 · PaywalledIn AML and CLL, 91% of VAMS venetoclax results fell within ±20% of plasma once an individualised haematocrit correction was applied; among patients trying home collection, 18 of 21 sampled independently and 76% of returned samples were analysable (home self-microsampling proved feasible).
Clinical validation of two volumetric absorptive microsampling devices to support home-based therapeutic drug monitoring of immunosuppressionLeino et al. · British Journal of Clinical Pharmacology · 2024 · PaywalledHead-to-head clinical validation of two VAMS devices for tacrolimus and mycophenolic acid, with roughly 86–88% of samples within ±20% of venous.
Volumetric Absorptive Microsampling in ToxicologyReview · Toxics · 2024 · Open accessConfirms urine is the second-most-applied VAMS matrix in forensics, collecting a consistent volume regardless of viscosity and enabling room-temperature storage and shipping.Open-access full text (PDF)
PediatricsNeoteryx Mitra
Therapeutic Drug Monitoring of Tacrolimus Based on VAMS in Renal Transplant Pediatric Recipients — LC-MS/MS Method, Hematocrit Effect, and Clinical ApplicationKocur et al. · Pharmaceutics · 2023 · Open accessA validated VAMS LC-MS/MS tacrolimus method in pediatric kidney-transplant recipients correlated strongly with the reference method, with minimal haematocrit impact.Open-access full text (PDF)
Pediatrics
VAMS and parallel-reaction-monitoring mass spectrometry for tacrolimus trough measurements at home in paediatric heart-transplant patientsZhao et al. · J. Mass Spectrometry and Advances in the Clinical Lab · 2023 · Open accessAt-home VAMS tacrolimus sampling showed no significant difference from clinic venipuncture, with stability through postal shipping and strong family acceptance.Open-access full text (PDF)
Analytical and Clinical Validation of Assays for VAMS of Drugs in Different Blood Matrices: A Literature ReviewNugraha et al. · Molecules · 2023 · Open accessA structured review: many VAMS assays are analytically validated and can substitute for venous sampling for well-characterised analytes, though clinical-validation depth varies.Open-access full text (PDF)
Clinical validation and feasibility of VAMS for monitoring of nilotinib, cabozantinib, dabrafenib, trametinib and ruxolitinibZimmermann et al. · J. Pharmaceutical and Biomedical Analysis · 2023 · PaywalledVAMS matched serum for the kinase inhibitors nilotinib, cabozantinib, dabrafenib and ruxolitinib (r 0.94–0.97; serum reliably predictable for the first three), and 93% of at-home samples were collected correctly (at-home VAMS shown feasible for routine cancer-drug monitoring).
Pediatrics
VAMS and dried plasma spot for antifungal triazole agents (voriconazole, posaconazole, isavuconazole) in pediatric patients by LC-MS/MSSimeoli et al. · J. Pharmaceutical and Biomedical Analysis · 2023 · PaywalledIn children, VAMS and dried plasma spot voriconazole, posaconazole and isavuconazole correlated with fresh plasma (Spearman 0.82–0.94) and stayed stable at room temperature for at least 14 days (refrigeration-free antifungal TDM in paediatrics).
Neoteryx Mitra
Quantification of 25-hydroxyvitamin D2 and D3 in Mitra devices (VAMS) by UHPLC-HRMS for regular vitamin D status monitoringTuma et al. · J. Pharmaceutical and Biomedical Analysis · 2023 · PaywalledA UHPLC-HRMS assay quantified 25-hydroxyvitamin D2 and D3 from 20 µL Mitra VAMS samples with accuracy under 10% and precision under 11% (LOQ 5 ng/mL) (sensitive enough to flag deficiency and simple enough for untrained self-collection, enabling year-round vitamin-D monitoring).
VAMS-based blood capillary sampling for mass-spectrometry-based human metabolomics studiesVolani et al. · Metabolites · 2023 · Open accessCapillary VAMS blood covered more of the metabolome than plasma (capturing intracellular red-cell metabolites) and correlated moderately-to-well with venous (Spearman 0.66); the honest caveats are higher finger-prick replicate variability and a need for −80 °C storage within six hours.Open-access full text (PDF)
A VAMS UPLC-MS/MS Method for Simultaneous Quantification of Tacrolimus, Mycophenolic Acid and Creatinine in Whole Blood of Renal Transplant RecipientsWang et al. · Pharmaceutics · 2022 · Open accessA single VAMS run quantified two immunosuppressants plus creatinine with minimal haematocrit effect (combined drug-and-organ-function monitoring from one dried tip).Open-access full text (PDF)
Neoteryx Mitra
Volumetric Absorptive Microsampling in Therapeutic Drug Monitoring of Immunosuppressive Drugs — From Sampling and Analytical Issues to Clinical ApplicationKocur & Pawiński · Int. J. Molecular Sciences · 2022 · Open accessA review positioning VAMS as state-of-the-art for immunosuppressant TDM: a fixed, accurate blood volume with a reduced haematocrit effect, home sampling and better adherence, especially in paediatric transplant (while flagging higher unit cost and a need for multicentre validation and cross-lab harmonisation before routine use).Open-access full text (PDF)
Pediatrics
Comparison of antibiotic sampling techniques: predicting plasma vancomycin from VAMS capillary versus venous/arterial whole bloodDownes et al. · Open Forum Infect. Dis. (IDWeek) · 2021 · Open accessThe honest counterpoint in children: VAMS predicted plasma vancomycin only modestly, venous/arterial VAMS was more accurate than capillary, and 29% of capillary samples were unusable for collection issues (collection technique and training matter as much as the assay).Open-access full text (PDF)
Neoteryx Mitra
Antibody-mediated immunity to SARS-CoV-2 and human coronaviruses: multiplex beads assay and VAMS to generate immune-repertoire cartographyWang et al. · Frontiers in Immunology · 2021 · Open accessFully remote, home-collected fingerstick VAMS (Mitra) samples from 54 participants measured IgG/IgA/IgM against spike and nucleocapsid across seven coronaviruses, cleanly separating pre-pandemic, convalescent and vaccinated groups (supporting VAMS for at-home serosurveillance).Open-access full text (PDF)
Neoteryx Mitra
Volumetric absorptive microsampling: its use in COVID-19 research and testingRudge · Bioanalysis · 2021 · Open accessA pandemic review of VAMS (Mitra): remotely self-collected home microsamples were shown to be as accurate as in-clinic samples for serology, keeping studies running when travelling to a clinic became risky.Open-access full text (PDF)
The evolving role of microsampling in therapeutic drug monitoring of monoclonal antibodies in inflammatory diseasesMingas et al. · Molecules · 2021 · Open accessA review of microsampling (VAMS and DBS) for TDM of therapeutic monoclonal antibodies (adalimumab, infliximab and others) in inflammatory disease: a convenient, home-friendly alternative to venepuncture that can preserve analytical accuracy, subject to assay-specific validation.Open-access full text (PDF)
Opportunities and obstacles for microsampling techniques in bioanalysis: special focus on DBS and VAMSLondhe & Rajadhyaksha · J. Pharmaceutical and Biomedical Analysis · 2020 · PaywalledA review contrasting the formats (framing the haematocrit effect, non-uniform spreading and homogeneity limits of DBS as the problems volumetric sampling is designed to solve).
Dried urine microsampling coupled to LC-MS/MS for the analysis of unconjugated anabolic-androgenic steroids— · Molecules · 2020 · Open accessA direct DUS-versus-VAMS comparison for 13 steroids on the same urine: VAMS gave better precision and recovery and superior one-year room-temperature stability.Open-access full text (PDF)
A validated VAMS-LC-MS/MS method to quantify doxycycline in urine: monitoring malaria-chemoprophylaxis compliance— · J. Analytical Methods in Chemistry · 2020 · Open accessUrine VAMS quantified doxycycline with 96–106% accuracy and 31-day room-temperature stability, supporting cold-chain-free adherence monitoring.Open-access full text (PDF)
Does volumetric absorptive microsampling eliminate the hematocrit bias for caffeine and paraxanthine in dried blood samples? A comparative studyDe Kesel, Lambert & Stove · Analytica Chimica Acta · 2015 · PaywalledVAMS eliminated the variable haematocrit bias seen with DBS, but a residual haematocrit-dependent recovery effect persisted at high haematocrit (the nuance that assays still need per-analyte validation).
Neoteryx Mitra
Volumetric Absorptive Microsampling: A Dried Sample Collection Technique for Quantitative BioanalysisDenniff & Spooner · Analytical Chemistry · 2014 · PaywalledThe foundational VAMS paper: a fixed ~10 µL is absorbed with under 5% volume variation across a 20–70% haematocrit range, overcoming the area bias and homogeneity problems of the dried blood spot.

External links open an open-access full text where one exists, otherwise the publisher or PubMed record. These citations describe the published evidence for the collection formats and devices (not claims about specific Humans Nexus assays, which are validated per analyte and per laboratory).

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