Neoteryx Mitra.
Exact volume, single touch.

Neoteryx Mitra is the volumetric absorptive microsampling device, VAMS: an absorbent tip that takes a fixed 10, 20 or 30 µL of capillary blood from a finger-prick in seconds, whatever the hematocrit, two or four tips to a device, so one finger-prick can fill up to four tips, each of which Humans Nexus can prepare with a different additive for a different assay. The tips dry and ship at ambient temperature for quantitative work, therapeutic drug monitoring above all. CE-IVD registered under the IVDR. Curated and supplied on the Humans Nexus platform; Neoteryx is the manufacturer.

Talk to salesHow it works →
Touch the drop. The tip fills itself.
The device

A fixed volume,
on a tip.

A Neoteryx Mitra volumetric absorptive microsampling device
The tip absorbs a fixed volume, which is what makes the sample quantitative.
A capillary blood sample being collected onto a Mitra microsampling tip from a fingertip
Collected from a fingertip, by the patient, without a tube or a centrifuge.
A Mitra microsampling kit being used away from a clinical setting
Dried on the tip, it travels at ambient temperature, with no cold chain to hold.

The Mitra device uses VAMS, volumetric absorptive microsampling. Touch its absorbent tip to a drop of blood on a fingertip and it wicks a fixed volume in seconds, 10, 20 or 30 µL, the same every time, whatever the hematocrit. You know it’s full when the tip turns fully red; the manufacturer specifies volumetric precision within about 5%, an RSD of 5% or better. The tip then dries, ships at ambient temperature with no cold chain, and needs no centrifugation before the laboratory elutes it and runs the assay. Humans Nexus curates and supplies the device on its platform; Neoteryx is the legal manufacturer. In the maker’s words, Mitra devices are CE-IVD devices under the IVDR, intended as specimen collectors for the storage and transport of blood and other biological fluids, registered as IVDs in the European Union, the United Kingdom, Australia, Brazil, China and Canada, and supplied as research use only in the United States.

Why it matters

Where the spot
falls short.

A traditional dried blood spot varies with volume and with hematocrit, which limits quantitation. VAMS captures a fixed volume on each tip, which the manufacturer designs for the reproducibility quantitative assays demand: therapeutic drug monitoring, LC-MS/MS small molecules, and biomarker panels transferred from venous methods.

Fixed volumeA known 10, 20 or 30 µL on every tip: within about 5%, an RSD of 5% or better, per the manufacturer.
Hematocrit-tolerantVAMS is designed to reduce the hematocrit-related volume bias seen with classic dried blood spots.
Ambient shippingThe dried tip is stable at room temperature and ships with no cold chain.
The evidence

What the record shows.

Each figure below belongs to the study that produced it. Mitra is named only where the paper’s abstract names it; VAMS is the format.

The founding paperAbout 10 µL absorbed in 2 to 4 seconds with under 5% volume variation across a hematocrit range of 20 to 70%, and no selective uptake of plasma over whole blood (Analytical Chemistry, 2014).
Hematocrit, honestlyOver 80 paired samples at hematocrit 0.21 to 0.50: no hematocrit-dependent bias for VAMS where dried blood spots had one, but a consistent positive bias and lower recovery at high hematocrit for the two model compounds. The reason every analyte is validated (Analytica Chimica Acta, 2015).
Mitra, finger-prick, in transplant care25 kidney-transplant recipients: finger-prick Mitra within 20% of venous for 88% of tacrolimus and 76% of mycophenolic-acid results (British Journal of Clinical Pharmacology, 2024).
Vitamin D from 20 µL25-hydroxyvitamin D2 and D3 from a 20 µL Mitra by UHPLC-HRMS: accuracy within 10%, precision within 11%, quantification limit 5 ng/mL, collected by medically untrained individuals (Journal of Pharmaceutical and Biomedical Analysis, 2023).
Cancer drugs, at home591 VAMS from 59 patients on kinase inhibitors: 93.1% of at-home samples collected correctly, no stability difference between on-site and at-home samples, r 0.94 to 0.97 against serum for four of the five drugs (Journal of Pharmaceutical and Biomedical Analysis, 2023).
Paediatric transplant, by post35 paediatric heart-transplant patients: no significant difference between VAMS and venous tacrolimus, dried tips stable for 14 days and unaffected by postal shipping (Journal of Mass Spectrometry and Advances in the Clinical Lab, 2024).

Every panel is validated per analyte, following the IATDMCT guideline on capillary-to-plasma conversion, before a result is reported. The full VAMS reading list follows below.

How it works

Touch. Dry. Return.

01Touch

Touch the tip to a fingertip drop; it wicks a fixed 10–30 µL in seconds and turns fully red when it’s done.

02Dry

The tip dries on its station, stable at ambient temperature.

03Return

Ships by tracked return with no cold chain; the lab elutes and runs the validated assay.

Two tips. One clean click open.
On the platform

Assembled into a kit.

Mitra is curated onto the platform and assembled into a regulated Humans Nexus collection kit: device, safety lancet, drying station, ambient-stable return packaging and instructions, under its own UDI.

The deviceNeoteryx Mitra VAMS tips at the fixed volume the programme requires.
The consumablesSafety lancet, drying station and ambient-stable, tamper-evident return packaging.
The guidanceApp-guided instructions for a clean fixed-volume collection.

See the kits →

A field team collecting a Mitra capillary microsample from a fingertip on a rocky mountainside
A lab-grade sample, collected anywhere.
Who it’s for

For quantitative work.

LaboratoriesA quantitative dried-blood format
Pharma & CRODecentralised trials and TDM
Digital healthPrecise home blood in-app
InsurersAccurate biomarker underwriting

Good to know.

How much blood does it take?

A fixed 10, 20 or 30 µL per tip, chosen for the assay, a fraction of a venous tube from a single finger-prick; a device carries two or four tips. The tip absorbs the same volume every time, RSD ≤ 5% per the manufacturer, and it turns fully red when it is full, which is what makes the dried sample quantitative.

How is Mitra different from a dried blood spot?

Mitra absorbs a fixed, known volume per tip, which the manufacturer designs to reduce the volume and hematocrit variability that limit traditional dried blood spots, so quantitative assays are more reliable.

What is VAMS best for?

Quantitative work: therapeutic drug monitoring, LC-MS/MS small-molecule assays, and biomarker panels transferred from venous methods. VAMS is widely used in TDM and PK research.

Does it need refrigeration?

No. The dried tip is stable at ambient temperature and ships by standard tracked return, with no cold chain.

Is Mitra CE marked?

Yes. In the maker’s words, Mitra devices are CE-IVD devices under the IVDR, registered as IVDs in the European Union, the United Kingdom, Australia, Brazil, China and Canada, and supplied as research use only in the United States. Device-level status is held by Neoteryx; each assay is validated per analyte before a patient-facing result.

Does hematocrit affect the result?

The tip’s volume does not: under 5% variation from 20 to 70% hematocrit in the founding study, and no hematocrit-dependent bias where the dried blood spot has one. Recovery can fall at high hematocrit for some analytes, so each is validated with a hematocrit-aware conversion where needed, following the IATDMCT guideline on the blood page.

Can patients collect Mitra samples at home?

Yes, with guidance. In cancer patients 93.1% of 591 at-home samples were collected correctly, and in paediatric heart transplant tacrolimus on the dried tip was unaffected by postal shipping. The honest counterpoint: in one pilot in critically ill children, 29% of capillary tips were unusable for collection issues, which is why collection is guided step by step in Flow.

How many tips per device, and can they differ?

Two or four tips to a device, so one finger-prick can fill up to four tips, and Humans Nexus can prepare each tip with a different additive, so one collection can serve more than one assay.

Who is the manufacturer?

Neoteryx makes the Mitra device. Humans Nexus curates and supplies it on the platform and assembles the regulated kit around it. Method validation runs per assay before patient-facing reporting.

OpenSampling Library by Humans Nexus

Library Neoteryx Mitra

Peer-reviewed studies that used Neoteryx Mitra, organised by where it is used: immunosuppressant, biologic, oncology and antimicrobial drug monitoring; biomarkers, vitamins and omics; infectious-disease serology; urine steroids and toxicology; and the haematocrit question the format was built to answer. Every paper opens its page in the OpenSampling Library, with a link to an open-access copy where one exists. This is evidence for the device, not a claim about any specific Humans Nexus assay.

Newest

  1. Clinical Validation of Venetoclax Volumetric Microsampling in Leukemia, with Whole-Blood-to-Plasma Conversion and Self-Microsampling Feasibility

    Clinical Pharmacokinetics · 2026 · Paywalled

    In AML and CLL, 91% of VAMS venetoclax results fell within 20% of plasma after individualised haematocrit correction; in home sampling, 18 of 21 patients self-sampled independently and 76% of returned samples were analysable,

    Read in the Library

  2. Volumetric Absorptive Microsampling During Spaceflight for Analysis of Acetaminophen Pharmacokinetics in Whole Blood

    Journal of clinical pharmacology · 2026 · Open access

    In four crew members, capillary volumetric absorptive microsampling caught altered acetaminophen pharmacokinetics in flight: Cmax rose to 43,300 ng/mL from 9,110 before flight and clearance fell to 3,890 mL/h from 16,200, pointing to

    Read in the Library

  3. Evaluation of hematocrit-adjusted conversion strategies for mycophenolic acid and tacrolimus monitoring using volumetric absorptive microsampling in lung and renal transplant recipients

    Journal of pharmacy & pharmaceutical sciences · 2026 · Open access

    In lung and renal transplant recipients, VAMS sampling with LC-MS/MS quantification of mycophenolic acid and tacrolimus showed good linearity and accuracy, and with a haematocrit-adjusted conversion formula achieved clinical agreement in most samples; tacrolimus did not require haematocrit correction. The approach is virtually painless and enables richer sampling for more

    Read in the Library

  4. Cefepime pharmacokinetics in critically ill children with multiple organ dysfunction syndrome using volumetric absorptive microsampling

    Antimicrobial agents and chemotherapy · 2026 · Open access

    In 15 critically ill children with multiple organ dysfunction, a population pharmacokinetic model built on volumetric absorptive microsamples found that estimated glomerular

    Read in the Library

  5. Volumetric absorptive microsampling for profiling of signaling lipids: a comparative analysis with whole blood and dried blood spots

    Analytical and bioanalytical chemistry · 2026 · Open access

    Volumetric absorptive microsampling showed better precision than dried blood spots and a metabolic profile closer to whole blood, with stable signalling lipids for 24 hours at room temperature but significant changes after one week

    Read in the Library

  6. Volumetric Absorptive Microsampling (VAMS) for Therapeutic Drug Monitoring of Antiseizure Medications (ASMs) in Pediatric Patients

    Pharmaceuticals · 2026 · Paywalled

    This study found that volumetric absorptive microsampling shows satisfactory agreement with venous plasma for monitoring several antiseizure medications in paediatric patients. However, a blood-to-plasma conversion factor was required to estimate plasma concentrations

    Read in the Library

All 158 in the OpenSampling Library

Method validation

  1. Clinical Validation of Venetoclax Volumetric Microsampling in Leukemia, with Whole-Blood-to-Plasma Conversion and Self-Microsampling Feasibility

    Clinical Pharmacokinetics · 2026 · Paywalled

    In AML and CLL, 91% of VAMS venetoclax results fell within 20% of plasma after individualised haematocrit correction; in home sampling, 18 of 21 patients self-sampled independently and 76% of returned samples were analysable,

    Read in the Library

  2. Evaluation of hematocrit-adjusted conversion strategies for mycophenolic acid and tacrolimus monitoring using volumetric absorptive microsampling in lung and renal transplant recipients

    Journal of pharmacy & pharmaceutical sciences · 2026 · Open access

    In lung and renal transplant recipients, VAMS sampling with LC-MS/MS quantification of mycophenolic acid and tacrolimus showed good linearity and accuracy, and with a haematocrit-adjusted conversion formula achieved clinical agreement in most samples; tacrolimus did not require haematocrit correction. The approach is virtually painless and enables richer sampling for more

    Read in the Library

  3. Volumetric absorptive microsampling for profiling of signaling lipids: a comparative analysis with whole blood and dried blood spots

    Analytical and bioanalytical chemistry · 2026 · Open access

    Volumetric absorptive microsampling showed better precision than dried blood spots and a metabolic profile closer to whole blood, with stable signalling lipids for 24 hours at room temperature but significant changes after one week

    Read in the Library

  4. Volumetric Absorptive Microsampling (VAMS) for Therapeutic Drug Monitoring of Antiseizure Medications (ASMs) in Pediatric Patients

    Pharmaceuticals · 2026 · Paywalled

    This study found that volumetric absorptive microsampling shows satisfactory agreement with venous plasma for monitoring several antiseizure medications in paediatric patients. However, a blood-to-plasma conversion factor was required to estimate plasma concentrations

    Read in the Library

  5. Application of volumetric absorptive microsampling (VAMS) for the simultaneous determination of cadmium and lead in blood

    Environmental monitoring and assessment · 2026 · Paywalled

    VAMS gave near‑quantitative recovery for cadmium and lead in human blood and correlated strongly with venous sampling, with pre‑cleaning improving correlation and lowering background lead,

    Read in the Library

  6. Systematic evaluation of propofol population pharmacokinetic models and development of a literature-supported new meta-model for critically ill preterm and term neonates

    European journal of pharmaceutical sciences · 2026 · Paywalled

    This study employed volumetric absorptive microsampling to collect blood samples from neonates, revealing that existing propofol pharmacokinetic models poorly predicted drug levels in this population. A newly developed meta-model provided accurate predictions, validating the use of

    Read in the Library

All 131 in the OpenSampling Library

Haematocrit

  1. Clinical Validation of Venetoclax Volumetric Microsampling in Leukemia, with Whole-Blood-to-Plasma Conversion and Self-Microsampling Feasibility

    Clinical Pharmacokinetics · 2026 · Paywalled

    In AML and CLL, 91% of VAMS venetoclax results fell within 20% of plasma after individualised haematocrit correction; in home sampling, 18 of 21 patients self-sampled independently and 76% of returned samples were analysable,

    Read in the Library

  2. Evaluation of hematocrit-adjusted conversion strategies for mycophenolic acid and tacrolimus monitoring using volumetric absorptive microsampling in lung and renal transplant recipients

    Journal of pharmacy & pharmaceutical sciences · 2026 · Open access

    In lung and renal transplant recipients, VAMS sampling with LC-MS/MS quantification of mycophenolic acid and tacrolimus showed good linearity and accuracy, and with a haematocrit-adjusted conversion formula achieved clinical agreement in most samples; tacrolimus did not require haematocrit correction. The approach is virtually painless and enables richer sampling for more

    Read in the Library

  3. Development and application of an LC-MS/MS method for 8 antiepileptic drugs and 2 metabolites using microsampling techniques (DBS and VAMS)

    Journal of analytical toxicology · 2026 · Open access

    The study validated an LC-MS/MS method for eight antiepileptic drugs and two metabolites in dried blood spot and VAMS formats, with satisfactory analytical performance and stability, and was the first to include the oxcarbazepine metabolite DHCB. In 80 paired patient samples, microsampling concentrations showed promising correlation

    Read in the Library

  4. Multi-Matrix LC-MS/MS Validation of Methotrexate Polyglutamates: Comparison of VAMS, DBS, and Conventional Blood Sampling in Rheumatoid Arthritis

    International journal of molecular sciences · 2026 · Open access

    In matched clinical samples from rheumatoid arthritis, VAMS and DBS showed strong agreement for methotrexate polyglutamates (slopes 0.95-1.07; bias within -4.21% to 0.36%; SRCC ≥ 0.969), with up to 100% of total MTXPG results within ±20% limits; capillary microsampling agreed closely with whole blood but

    Read in the Library

  5. Simultaneous quantification of linezolid and its metabolites (PNU-142300 and PNU-142586) in oral fluid and capillary blood by UPLC-MS/MS: method validation and clinical application using non-invasive sampling techniques

    Journal of translational medicine · 2026 · Paywalled

    A UPLC-MS/MS method for linezolid and metabolites in oral fluid and VAMS capillary blood satisfied ICH M10 validation requirements. Linezolid concentrations correlated strongly with venous plasma in both matrices, offering a non‑invasive option for

    Read in the Library

  6. Analytical and usability comparison of microsampling dried blood spot devices for glucocorticoid detection in sports using ultra-high-performance liquid chromatography-tandem mass spectrometry

    Analytica chimica acta · 2025 · Paywalled

    This study compared four dried blood spot devices for glucocorticoid detection, finding that the Mitra VAMS device offered the best combination of analytical recovery

    Read in the Library

All 34 in the OpenSampling Library

Biomarkers, vitamins & omics

  1. Volumetric absorptive microsampling for profiling of signaling lipids: a comparative analysis with whole blood and dried blood spots

    Analytical and bioanalytical chemistry · 2026 · Open access

    Volumetric absorptive microsampling showed better precision than dried blood spots and a metabolic profile closer to whole blood, with stable signalling lipids for 24 hours at room temperature but significant changes after one week

    Read in the Library

  2. A feasibility study exploring precarious employment and stress-related health among women

    BMC public health · 2026 · Open access

    Among 101 working-age women in Chicago, 70% returned at-home kits for capillary blood and saliva collection, demonstrating that patient-centric microsampling of stress biomarkers (cortisol and CRP) is feasible in diverse urban populations. This supports decentralised

    Read in the Library

  3. An LC-MS untargeted metabolomic comparison between three blood microsampling devices, whole blood, and plasma

    Metabolomics · 2026 · Open access

    Untargeted metabolomic profiles from three blood microsampling devices aligned more closely with whole blood than with plasma, and all devices distinguished sex based on amino acids, lipids, and acylcarnitines. This validates that device choice can be tailored to the

    Read in the Library

  4. Development and Validation of a Streamlined Workflow for Proteomic Analysis of Proteins and Post-translational Modifications from Dried Blood

    Journal of proteome research · 2026 · Paywalled

    A streamlined workflow quantified up to 10,000 protein groups and post-translational modifications from 20 microlitres of dried blood collected by volumetric absorptive microsampling, with mass spectrometry acquisition under two hours. The study established stability profiles and best practices for dried blood proteomics,

    Read in the Library

  5. Reference values for the alcohol biomarker phosphatidylethanol (PEth) in the Belgian population: Insights from a nationwide microsampling study

    Drug and alcohol dependence reports · 2026 · Open access

    PEth reference values for Belgium were derived from VAMS microsampling of 487 participants in a national survey, showing distinct biomarker distributions between the general population and higher‑alcohol‑consumption subgroups. This validates capillary blood collection as a practical

    Read in the Library

  6. A validated method for capillary phosphatidylethanol 16:0/18:1 quantification with two different 10-µl volumetric absorptive microsample devices in the same setup

    Journal of analytical toxicology · 2025 · Paywalled

    This study validated a method for measuring the alcohol biomarker phosphatidylethanol using two volumetric absorptive microsampling devices, finding that the Mitra device met all validation criteria and agreed with venous sampling. The Capitainer device was deemed suitable but showed reduced accuracy at higher

    Read in the Library

All 26 in the OpenSampling Library

Immunosuppressants

  1. Evaluation of hematocrit-adjusted conversion strategies for mycophenolic acid and tacrolimus monitoring using volumetric absorptive microsampling in lung and renal transplant recipients

    Journal of pharmacy & pharmaceutical sciences · 2026 · Open access

    In lung and renal transplant recipients, VAMS sampling with LC-MS/MS quantification of mycophenolic acid and tacrolimus showed good linearity and accuracy, and with a haematocrit-adjusted conversion formula achieved clinical agreement in most samples; tacrolimus did not require haematocrit correction. The approach is virtually painless and enables richer sampling for more

    Read in the Library

  2. Multi-Matrix LC-MS/MS Validation of Methotrexate Polyglutamates: Comparison of VAMS, DBS, and Conventional Blood Sampling in Rheumatoid Arthritis

    International journal of molecular sciences · 2026 · Open access

    In matched clinical samples from rheumatoid arthritis, VAMS and DBS showed strong agreement for methotrexate polyglutamates (slopes 0.95-1.07; bias within -4.21% to 0.36%; SRCC ≥ 0.969), with up to 100% of total MTXPG results within ±20% limits; capillary microsampling agreed closely with whole blood but

    Read in the Library

  3. Volumetric Absorptive Microsampling of Saliva for Pharmacokinetic Evaluation of Mycophenolic Acid and Its Glucuronide Metabolite in Pediatric Renal Transplant Recipients: Bioanalytical Method Validation and Clinical Feasibility Evaluation

    Pharmaceuticals · 2025 · Open access

    Dried saliva collected with the Mitra device correlated strongly with wet saliva but poorly with plasma unbound and total concentrations, indicating it is not a reliable substitute for plasma in routine therapeutic drug monitoring of mycophenolic acid and its glucuronide metabolite. Capillary blood collected via VAMS remains a promising

    Read in the Library

  4. Therapeutic Drug Monitoring of Everolimus Using Volumetric Absorptive Microsampling and Quantitative Dried Blood Spot Methods with LC-MS/MS in Adult Solid Organ Transplant Recipients: An Analytical and Clinical Comparative Study

    Molecules · 2025 · Open access

    A validated LC-MS/MS method for everolimus using Mitra and Capitainer devices found excellent agreement between capillary microsamples and venous whole blood in 33 adult transplant recipients. The results showed high accuracy and negligible haematocrit effects,

    Read in the Library

  5. An Offline SPE-LC-MS/MS Method for Simultaneous Quantification of Tacrolimus, Cyclosporine A, Kynurenine, Tryptophan, and Creatinine Using Volumetric Absorptive Microsampling Device Mitra

    Therapeutic drug monitoring · 2025 · Open access

    A validated offline SPE-LC-MS/MS method using the Mitra microsampling device successfully quantified tacrolimus, cyclosporine A, tryptophan, kynurenine, and creatinine simultaneously. The method met EMA and FDA criteria, showing agreement between capillary and venous sampling, which could

    Read in the Library

  6. Clinical validation of two volumetric absorptive microsampling devices to support home-based therapeutic drug monitoring of immunosuppression

    British Journal of Clinical Pharmacology · 2024 · Paywalled

    Head-to-head clinical validation of two VAMS devices for tacrolimus and mycophenolic acid, with roughly 86–88% of samples within ±20% of venous.

    Read in the Library

All 26 in the OpenSampling Library

Toxicology & doping

  1. Application of volumetric absorptive microsampling (VAMS) for the simultaneous determination of cadmium and lead in blood

    Environmental monitoring and assessment · 2026 · Paywalled

    VAMS gave near‑quantitative recovery for cadmium and lead in human blood and correlated strongly with venous sampling, with pre‑cleaning improving correlation and lowering background lead,

    Read in the Library

  2. Volumetric absorptive microsampling device for forensic Toxicologic screening: A case report as proof-of-concept

    Forensic science international · 2026 · Paywalled

    A post-mortem case study found that Mitra microsampling devices achieved comparable qualitative toxicological detection to conventional methods across blood, urine, bile, and vitreous humour, successfully identifying methamphetamine, opioids, and alpha-PHP. Whilst limited to a single case, this shows that microsampling is a viable

    Read in the Library

  3. Stressing the limits of capillary blood in anti-doping analysis: perspectives on alkylamine-like stimulants and carbonic anhydrase II inhibitors in result management

    Frontiers in sports and active living · 2026 · Open access

    Capillary blood collected by volumetric absorptive microsampling gave a shorter detection window than urine for a stimulant, helping to distinguish recent from earlier use, and more reliable detection of long-acting diuretics that bind red cells. This shows microsampling can improve interpretation in

    Read in the Library

  4. Reference values for the alcohol biomarker phosphatidylethanol (PEth) in the Belgian population: Insights from a nationwide microsampling study

    Drug and alcohol dependence reports · 2026 · Open access

    PEth reference values for Belgium were derived from VAMS microsampling of 487 participants in a national survey, showing distinct biomarker distributions between the general population and higher‑alcohol‑consumption subgroups. This validates capillary blood collection as a practical

    Read in the Library

  5. LC-HRMS screening for 11 classes of prohibited substances in dried urine spots for doping control

    Analytical and Bioanalytical Chemistry · 2025 · Paywalled

    A multi-targeted procedure covered 237 prohibited substances across 11 WADA classes in dried urine spots, with

    Read in the Library

  6. A validated method for capillary phosphatidylethanol 16:0/18:1 quantification with two different 10-µl volumetric absorptive microsample devices in the same setup

    Journal of analytical toxicology · 2025 · Paywalled

    This study validated a method for measuring the alcohol biomarker phosphatidylethanol using two volumetric absorptive microsampling devices, finding that the Mitra device met all validation criteria and agreed with venous sampling. The Capitainer device was deemed suitable but showed reduced accuracy at higher

    Read in the Library

All 21 in the OpenSampling Library

Antimicrobial & antifungal TDM

  1. Cefepime pharmacokinetics in critically ill children with multiple organ dysfunction syndrome using volumetric absorptive microsampling

    Antimicrobial agents and chemotherapy · 2026 · Open access

    In 15 critically ill children with multiple organ dysfunction, a population pharmacokinetic model built on volumetric absorptive microsamples found that estimated glomerular

    Read in the Library

  2. Simultaneous quantification of linezolid and its metabolites (PNU-142300 and PNU-142586) in oral fluid and capillary blood by UPLC-MS/MS: method validation and clinical application using non-invasive sampling techniques

    Journal of translational medicine · 2026 · Paywalled

    A UPLC-MS/MS method for linezolid and metabolites in oral fluid and VAMS capillary blood satisfied ICH M10 validation requirements. Linezolid concentrations correlated strongly with venous plasma in both matrices, offering a non‑invasive option for

    Read in the Library

  3. Determination of Fluconazole in Children in Small Blood Volumes Using Volumetric Absorptive Microsampling (VAMS) and Isocratic High-Performance Liquid Chromatography-Ultraviolet (HPLC-UV) Detection

    Pharmaceutics · 2025 · Open access

    This study validated a method for quantifying fluconazole using the Mitra device, demonstrating sufficient accuracy and precision for

    Read in the Library

  4. The comparison of two volumetric microsampling devices (qDBS and VAMS) for determining ganciclovir levels in capillary blood using the LC-MS/MS technique in pediatric renal transplant recipients

    European journal of pharmaceutical sciences · 2025 · Paywalled

    The study compared quantitative dried blood spot (qDBS) and volumetric absorptive microsampling (VAMS) devices for measuring ganciclovir levels in capillary blood from pediatric renal transplant recipients. This comparison provides evidence for choosing between microsampling devices in therapeutic drug monitoring,

    Read in the Library

  5. A comparison between venous blood sampling and capillary volumetric absorptive microsampling for antibiotics levels monitoring in individuals with and without periodontal disease

    Clinical oral investigations · 2025 · Open access

    Capillary volumetric absorptive microsampling showed significant differences in absolute antibiotic concentrations compared to venous plasma, yet it reliably tracked the pharmacokinetic profiles of amoxicillin, metronidazole, and azithromycin over time. The approach was well accepted by both participants and clinicians, indicating its

    Read in the Library

  6. Development and validation of ivermectin quantification method in volumetric absorptive microsampling using liquid chromatography-tandem mass spectrometry

    Heliyon · 2024 · Open access

    The authors validated a VAMS method for ivermectin therapeutic drug monitoring in whole blood, achieving a lower limit of quantification of 1 ng/mL and a linear range of 1–150 ng/mL. By eliminating haematocrit effects that limit dried blood spots, the

    Read in the Library

All 14 in the OpenSampling Library

Oncology drug monitoring

  1. Clinical Validation of Venetoclax Volumetric Microsampling in Leukemia, with Whole-Blood-to-Plasma Conversion and Self-Microsampling Feasibility

    Clinical Pharmacokinetics · 2026 · Paywalled

    In AML and CLL, 91% of VAMS venetoclax results fell within 20% of plasma after individualised haematocrit correction; in home sampling, 18 of 21 patients self-sampled independently and 76% of returned samples were analysable,

    Read in the Library

  2. HPLC-MS Quantification of Multiple Tyrosine Kinase Inhibitors in Patients with Solid Tumors: Method Validation and Clinical Application

    Pharmaceutics · 2026 · Paywalled

    The study developed and validated a reliable HPLC-MS method for quantifying multiple tyrosine kinase inhibitors from VAMS microsamples of capillary blood, showing acceptable accuracy, precision, and 28-day stability at -21°C, with results comparable to venous plasma in 194 samples from patients with solid tumours. This enables therapeutic drug monitoring

    Read in the Library

  3. Clinical Application of Volumetric Absorptive Microsampling for Therapeutic Drug Monitoring of Oral Targeted Anticancer Drugs

    Therapeutic drug monitoring · 2025 · Open access

    This study established conversion methods for estimating plasma concentrations from whole blood VAMS samples for seven out of ten oral anticancer drugs, finding good agreement between capillary and venous samples. Patients reported a positive experience with

    Read in the Library

  4. Comparison of capecitabine concentrations determined by microsampling versus plasma concentrations for therapeutic drug monitoring: a pilot study

    The Journal of pharmacy and pharmacology · 2024 · Paywalled

    Microsampling with Mitra® devices correlated strongly with venous plasma for capecitabine therapeutic drug monitoring (r=0.97), but yielded consistently lower concentrations. Patients preferred this method and reported minimal pain, suggesting it is

    Read in the Library

  5. Towards clinical adherence monitoring of oral endocrine breast cancer therapies by LC-HRMS-method development, validation, comparison of four sample matrices, and proof of concept

    Analytical and bioanalytical chemistry · 2024 · Open access

    The study validated an LC-HRMS method for measuring breast cancer drugs in plasma, urine, VAMS and oral fluid, showing that all matrices except oral fluid for certain drugs can support decentralised therapeutic drug monitoring. VAMS and oral fluid faced practical challenges in collection due to patient conditions, but

    Read in the Library

  6. Factors affecting peripheral neuropathy induced by nanoparticle albumin-bound paclitaxel in patients with pancreatic cancer

    British journal of clinical pharmacology · 2024 · Open access

    The study found that higher cumulative doses and more treatment cycles of nab-paclitaxel, along with older age, are linked to increased frequency and severity of peripheral neuropathy in pancreatic cancer patients. VAMS was shown to be a feasible, minimally invasive alternative to venous sampling

    Read in the Library

All 13 in the OpenSampling Library

Serology & infectious disease

  1. Comparison of capillary microsampling and venous blood for multi-pathogen serosurveillance

    Scientific reports · 2026 · Paywalled

    Capillary samples collected using dried blood spots and Mitra microsamplers showed strong agreement with venous plasma for quantifying IgG antibodies against most vaccine-preventable diseases. Sensitivity was high for the majority of pathogens, though the study noted that antibody

    Read in the Library

  2. Validation of at-home blood sampling for large scale, cost effective serological analysis for anti-viral antibody responses

    Journal of immunological methods · 2025 · Paywalled

    The study found very strong correlation between venous blood collection and capillary VAMS using Mitra devices for detecting SARS-CoV-2 spike antibodies, with samples remaining stable at room temperature for several months. This enables reliable at-home, patient-centric serological

    Read in the Library

  3. Performance and feasibility of self-microsampling of capillary blood and saliva for serological testing of SARS-CoV-2

    PloS one · 2025 · Open access

    Capillary blood self-collected with the VAMS device showed 100 per cent agreement with serum for detecting SARS-CoV-2 S RBD antibodies in participants with known past infection, and saliva showed slightly lower but high agreement; agreement was good to almost perfect in those without known

    Read in the Library

  4. Validation of Trypanosoma cruzi inactivation techniques for laboratory use

    PloS one · 2024 · Open access

    Three freeze-thaw cycles, Virkon disinfectant, and air drying on Mitra microsamplers for two hours each inactivated Trypanosoma cruzi in spiked blood, while FTA C cards failed. These validated methods permit safe removal of infectious samples from

    Read in the Library

  5. Clinical sensitivity and specificity of a high-throughput microfluidic nano-immunoassay combined with capillary blood microsampling for the identification of anti-SARS-CoV-2 Spike IgG serostatus

    PloS one · 2023 · Open access

    In participants 11 months after SARS-CoV-2 infection, the nano-immunoassay achieved 98.33% sensitivity and 97.62% specificity on venous serum. When combined with dried capillary microsampling, sensitivity was 95.05% with Mitra, 61.11% with repurposed glucose

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  6. Antibody-mediated immunity to SARS-CoV-2 and human coronaviruses: multiplex beads assay and VAMS to generate immune-repertoire cartography

    Frontiers in Immunology · 2021 · Open access

    Fully remote, home-collected fingerstick Mitra VAMS samples from 54 participants measured IgG/IgA/IgM against spike and nucleocapsid across seven coronaviruses, cleanly separating pre-pandemic,

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All 10 in the OpenSampling Library

Biologic & monoclonal-antibody TDM

  1. Evaluation of Patient-Centric Sample Collection Technologies for Pharmacokinetic Assessment of Large and Small Molecules

    Clinical pharmacology and therapeutics · 2024 · Paywalled

    Capillary blood collection using liquid and dried microsampling devices yielded pharmacokinetic profiles comparable to venous sampling for two monoclonal antibodies and a small molecule, whereas haematocrit correction was necessary for dried formats and bridging was ineffective for hydroxychloroquine. The findings demonstrate the bioanalytical feasibility and patient acceptability of

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  2. Volumetric absorptive microsampling coupled with hybridization LC-MS/MS for quantitation of antisense oligonucleotides

    Bioanalysis · 2023 · Paywalled

    The authors developed and validated a workflow that couples Mitra volumetric absorptive microsampling with hybridisation LC-MS/MS to quantify the antisense oligonucleotide fomivirsen in human blood. Quantitative recovery was achieved irrespective of haematocrit level or sample age, and the method demonstrated

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  3. Promising Tools to Facilitate the Implementation of TDM of Biologics in Clinical Practice

    Journal of clinical medicine · 2022 · Open access

    In a small substudy of psoriasis patients, lateral flow testing for adalimumab agreed very well with ELISA (r=0.95, R2=0.89) and capillary VAMS from finger prick correlated strongly with serum (r=0.87), while patients found home

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  4. Infliximab Level Between Venous and Capillary Blood Using Novel Device Strongly Correlate in Paediatric Inflammatory Bowel Disease Patients

    Journal of pediatric gastroenterology and nutrition · 2021 · Paywalled

    In paediatric inflammatory bowel disease patients, infliximab levels measured from dried capillary blood spots strongly correlated with venous serum concentrations, with a mean difference of -0.14 μg/mL and excellent interclass correlation coefficient of 0.998. This demonstrates that

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  5. Assessment of low volume sampling technologies: utility in nonclinical and clinical studies

    Bioanalysis · 2021 · Paywalled

    Two feasibility studies assessed low-volume blood sampling for therapeutic drug monitoring. In patients receiving an anti-A therapeutic, drug levels were measured from finger-prick whole blood collected with

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  6. Dried blood samples can support monitoring of infliximab concentrations in patients with inflammatory bowel disease: A clinical validation

    British Journal of Clinical Pharmacology · 2019 · Open access

    A clinical validation showing dried blood samples can support infliximab concentration monitoring in inflammatory bowel disease.

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All 7 in the OpenSampling Library

Steroids (urine)

  1. Dried urine microsampling coupled to LC-MS/MS for the analysis of unconjugated anabolic-androgenic steroids

    Molecules · 2020 · Open access

    A direct DUS-versus-VAMS comparison for 13 steroids on the same urine: VAMS gave better precision and recovery and

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These citations describe the published evidence for the collection formats and devices, not claims about specific Humans Nexus assays, which are validated per analyte and per laboratory.

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