The first blood test,
without the first tear.

Every parent knows the sound of needle fear (the gripped sleeve, the night-before dread). For children, and for anyone with needle phobia or a learning disability, the venepuncture chair is where healthcare breaks down. Pediatric microsampling rewrites the scene: a small touch-activated device on the upper arm, applied by a healthcare professional (a halo of microneedles, not a blade). No white knuckles. No held-down child. A blood test that ends in a sticker, not a tear.

Stickers first. Then the arm.
Why children

Small veins, big fear.

A TAP capillary collector on a newborn's upper arm during a blood collection
On a newborn, where a heel prick would otherwise be the only option.
A child having a capillary blood sample collected from the upper arm with a TAP device
On the upper arm, without a phlebotomist and without a needle in view.
A TAP collection device decorated with children's stickers
Decorated by the child it belongs to. Children describe it as a sticker.

A child doesn’t remember the diagnosis. They remember being held down. Pediatric venipuncture fails where it hurts most: small veins mean repeat attempts, repeat attempts mean restraint, and restraint teaches a child that medicine is something done to them. So parents postpone the next test, and the clinical picture goes blank exactly where growing bodies change fastest.

The fear compoundsNeedle phobia formed at six follows a patient for sixty years, every skipped test starts here.
Veins don’t cooperatePediatric draws routinely take more than one attempt. Each attempt costs blood, time and trust.
Care goes blindPostponed tests and under-recruited pediatric trials leave children’s medicine running on less data than any other age group.
The device

Stickers on, fear off.

The platform’s answer is YourBio TAP (touch-activated, applied to the upper arm) a halo of microneedles, not a blade. In a peer-reviewed study, most participants preferred it to a needle (63% versus 7%). The children decorate the device with stickers before it goes on, a healthcare professional applies it with the parent right there, and the sample is done before the fear has anywhere to start. For infants, collection is demonstrated from the thigh, held in a parent’s arms. In children the device is used under healthcare-professional supervision (at-home self-collection is for adults).

The YourBio device on the platform →

A clinician’s hands. A parent beside.
A true story · in the NHS

“Great fun,” said Abi.
About a blood test.

Abi is fifteen. She has Down’s syndrome, and her thyroxine treatment needs regular blood monitoring, which for years meant everything a needle means to a frightened teenager. Then University Hospitals of Morecambe Bay NHS Foundation Trust became the first NHS trust to offer TAP collection for people with learning disabilities, in a programme led by Karen Perkins, Principal Clinical Scientist. Since April 2025 the team has collected samples from nearly fifty patients who previously could not give blood at all, and six more NHS trusts have asked for their data to replicate the model.

~50patients who previously couldn’t give blood, sampled since April 2025
6more NHS trusts asking for the data to replicate the model
1stNHS trust to offer TAP for people with learning disabilities

“TAP really is a game changer for Abi, and I’m sure many others like her.”

Abi’s mother · University Hospitals of Morecambe Bay NHS Foundation Trust

“The fear of your child dying never goes away. Now I know I can keep her well.”

Lucy’s mother · Lucy, 16, has Down’s syndrome and autism · University Hospitals of Morecambe Bay NHS Foundation Trust

Abigail's StoryBlood Sciences, University Hospitals of Morecambe Bay NHS Foundation Trust · 5:09

Nothing loads from YouTube until you press play (no third-party request, no cookie, before that). The film is Blood Sciences, University Hospitals of Morecambe Bay NHS Foundation Trust’s, not ours. Watch it on YouTube →

Read the story at the Royal College of Pathologists  ·  the Trust’s announcement

Quotes and figures from the Royal College of Pathologists and University Hospitals of Morecambe Bay NHS Foundation Trust. TAP is the YourBio device curated on the Humans Nexus platform; the Morecambe Bay programme is the Trust’s own work. Pediatric microsampling and paediatric microsampling are the same practice, the American and British spellings of one idea.

The evidence

Not a promise. A record.

We won’t ask you to take “painless” on faith, and we won’t put the word in the manufacturer’s mouth (it comes from independent, peer-reviewed research and the clinicians who use it). In an Oxford trial published in Diabetes Care, 63% of participants (children and adults) preferred the device to a needle and just 7% preferred the needle; Oxford judged it a reliable, highly accurate alternative to a venous draw, with far less post-collection bruising (about 6% versus 35% after a needle). At Massachusetts General Hospital, published in JAMA, it drew blood from infants as young as two months, chosen to avoid a painful heel prick.

63%preferred it to a needle, just 7% preferred the needleBesser et al. · Diabetes Care 2024
100%sensitivity & specificity for detecting a clinically relevant C-peptide level (≥200 pmol/L)Besser et al. · Diabetes Care 2024
2 mothe youngest infants sampled, to avoid a heel prickMGH / Edlow Lab · JAMA 2022

“We are using a microneedle sticker device that collects surface capillary blood from the babies in order to avoid a painful heel prick/venipuncture.”

Edlow Lab · Massachusetts General Hospital · edlowlab.org
Independent & peer-reviewed
PediatricsYourBio
Transdermal blood sampling for C-peptide is a minimally invasive, reliable alternative to venous sampling in children and adults with type 1 diabetesBesser et al. · Diabetes Care 2024;47(2):239 · Oxford University Hospitals91 participants, children and adults. Capillary C-peptide from the TAP device matched venous results with 100% sensitivity and specificity for detecting a clinically relevant level (≥200 pmol/L; correlation r = 0.996); 63% preferred it to a needle and just 7% preferred the needle, and post-collection bruising was far less common than after a venous draw (5.5% versus 34.8% on the day of collection).Open-access full text (PDF)
PediatricsYourBio
Durability of anti-spike antibodies in infants after maternal COVID-19 vaccination or natural infectionShook, Edlow et al. · JAMA 2022 · Massachusetts General HospitalThe paper states the TAP II blood-collection devices for the infant draws were provided by YourBio Health; capillary serum was collected from babies as young as two months (the smallest patients, sampled without a heel prick or a venipuncture).Open-access full text (PDF)
PediatricsYourBio
O’Ryan.Health launches parent-led pediatric studies using YourBio TAPPR Newswire · 31 July 2024 · O’Ryan.Health & YourBio HealthTwo IRB-approved observational studies (one in ultra-rare juvenile dermatomyositis) built on capillary blood collected from children, on a schedule, without a trip to the clinic.

These are independent studies of the YourBio TAP device that Humans Nexus curates on its platform (not our own trials); the maker supplied the devices but, per the papers, had no role in their design or analysis. On the Humans Nexus platform, children are collected under healthcare-professional supervision; the at-home collections above were conducted within IRB-approved research protocols.

Also on the platform · dried blood

For the children who need it often.

The lancet-free upper-arm draw is one path. For a child with a chronic condition (a transplant, an autoimmune disease) who needs a drug level checked again and again, the platform also offers the Neoteryx Mitra device: a fixed-volume dried-blood microsample from a single fingertip, taken at home instead of a repeat venous draw. A different tool for a different job (quantitative drug monitoring) and the evidence in children is real.

r = 0.95home dried-blood agreed with a clinic venous draw for tacrolimusZhao et al. · pediatric heart transplant · 2023
83%of families found home sampling easy, and would do it againZhao et al. · satisfaction survey
0children who declined to keep collecting at homeZhao et al. · 2023

Validated in children for transplant immunosuppressants and antifungal drug levels. The Mitra device on the platform →

Pediatric evidence

Dried-blood microsampling in children

Peer-reviewed evidence for volumetric absorptive microsampling (the Mitra format) in pediatric drug monitoring: at-home tacrolimus after transplant, antifungal levels, and the honest limits, each with an open-access full text where one exists.

4 papers

Sample type

Collection format

Device

Topic

Access

PediatricsNeoteryx Mitra
Therapeutic Drug Monitoring of Tacrolimus Based on VAMS in Renal Transplant Pediatric Recipients — LC-MS/MS Method, Hematocrit Effect, and Clinical ApplicationKocur et al. · Pharmaceutics · 2023 · Open accessA validated VAMS LC-MS/MS tacrolimus method in pediatric kidney-transplant recipients correlated strongly with the reference method, with minimal haematocrit impact.Open-access full text (PDF)
Pediatrics
VAMS and parallel-reaction-monitoring mass spectrometry for tacrolimus trough measurements at home in paediatric heart-transplant patientsZhao et al. · J. Mass Spectrometry and Advances in the Clinical Lab · 2023 · Open accessAt-home VAMS tacrolimus sampling showed no significant difference from clinic venipuncture, with stability through postal shipping and strong family acceptance.Open-access full text (PDF)
Pediatrics
VAMS and dried plasma spot for antifungal triazole agents (voriconazole, posaconazole, isavuconazole) in pediatric patients by LC-MS/MSSimeoli et al. · J. Pharmaceutical and Biomedical Analysis · 2023 · PaywalledIn children, VAMS and dried plasma spot voriconazole, posaconazole and isavuconazole correlated with fresh plasma (Spearman 0.82–0.94) and stayed stable at room temperature for at least 14 days (refrigeration-free antifungal TDM in paediatrics).
Pediatrics
Comparison of antibiotic sampling techniques: predicting plasma vancomycin from VAMS capillary versus venous/arterial whole bloodDownes et al. · Open Forum Infect. Dis. (IDWeek) · 2021 · Open accessThe honest counterpoint in children: VAMS predicted plasma vancomycin only modestly, venous/arterial VAMS was more accurate than capillary, and 29% of capillary samples were unusable for collection issues (collection technique and training matter as much as the assay).Open-access full text (PDF)

External links open an open-access full text where one exists, otherwise the publisher or PubMed record. These citations describe the published evidence for the collection formats and devices (not claims about specific Humans Nexus assays, which are validated per analyte and per laboratory).

Held by a parent. Not a clinic.
Under supervision

A clinician’s hands, a guided Flow.

For children, collection happens under healthcare-professional supervision (at the practice, on the ward, at the point of care or on a supervised home-nursing visit). Flow carries the record: identity attested, consent recorded by the parent or guardian, collection confirmed. From there the sample follows the same route as every other (clinical courier pickup, documented chain of custody, an accredited laboratory) and the result returns to the pediatrician and the family under the programme’s release policy. At-home self-collection with YourBio is for adults.

You stay in the room. The stickers are her job (the rest is ours).

Flow, the patient companion →  ·  Identity & consent →

What it unlocks

Pediatric care, finally seen.

Pediatric trialsVisits families stop dreading (a gentle draw instead of a cannula, and cohorts that stay)
Chronic pediatric careEndocrinology, allergy and drug monitoring between visits, without a fight, without a gap
Infant follow-upRepeat sampling after newborn screening, without another venepuncture
Needle phobia & learning disabilitiesThe patients conventional phlebotomy leaves behind (as the NHS is now proving)
The draw that ends with a smile.

Good to know.

Is there a needle-free blood test for children?

Not needle-free, but there is no lancet and no venepuncture, which is the distinction that matters to a frightened child. TAP collects from the upper arm through a halo of microneedles rather than a blade: nothing to watch go in, and no fingertip squeeze. Applied by a healthcare professional, it draws a real whole-blood sample the laboratory runs like any other. It’s decorated with stickers before it goes on, and in published studies most participants preferred it to a needle.

Is it really painless for children?

The comfort claim isn’t ours or the manufacturer’s, it’s what independent studies and clinicians report. In an Oxford trial published in Diabetes Care, most participants (children and adults) preferred it to a needle (63% versus 7%) and Oxford judged it a reliable, highly accurate alternative. At Massachusetts General Hospital, clinicians use it on infants specifically to avoid a painful heel prick. In the NHS programme, Abi has said TAP was “great fun.” There is no visible needle and no venipuncture.

Does it work for needle phobia or learning disabilities?

That is where it has proven itself most. University Hospitals of Morecambe Bay NHS Foundation Trust (the first NHS trust to offer TAP for people with learning disabilities) has collected from nearly fifty patients since April 2025 who previously could not give blood at all, and other trusts are adopting the model.

What ages can use it?

The manufacturer demonstrates use across ages (upper-arm collection for children and adults, and thigh collection for infants held by a parent). In children the device is used under healthcare-professional supervision; adults may self-collect at home. Suitability for a specific programme and age group is confirmed per protocol with the laboratory.

Who collects the sample?

For children, a healthcare professional (at the practice, the point of care or a supervised visit) with the parent alongside and consent recorded by the parent or guardian in Flow. At-home self-collection with YourBio is for adults.

What can be tested?

The device collects liquid whole blood (the same matrix as a venous draw, in microsample volume) suitable for a broad validated panel confirmed with the accredited laboratory, from thyroid monitoring to drug levels.

How does the sample travel?

Like every sample the platform tracks: clinical courier pickup, temperature-managed where the assay requires it, documented chain of custody from collection to laboratory accessioning.

The evidence base

Everything published on collecting blood this way.

The peer-reviewed record for liquid capillary blood taken from the upper arm (the studies of this device, the studies of the ones beside it, and the honest limits). The same index serves the fertility page and the device page, so a paper cited in one place says the same thing in the others.

12 papers

Sample type

Collection format

Device

Topic

Access

Fertility
Larger-volume capillary blood sampling is a valid alternative to assess progesterone and 17β-estradiol for cycle phase identificationSchlie et al. · Frontiers in Physiology · 2025 · Open accessCapillary samples of 100–250 µL taken alongside venous draws twice weekly across a full menstrual cycle agreed closely for progesterone and 17β-estradiol (concordance 0.911 and 0.919, minimal bias) (accurate enough to classify cycle phase and to flag anovulatory or luteal-phase-deficient cycles). The capillary blood was taken from the earlobe, so this validates the matrix and the volume rather than any one collection device.Open-access full text (PDF)
YourBio
Comparing capillary blood collection technologies: patient experience, device performance and clinical accuracyCollier et al. · Bioanalysis · 2025 · PaywalledA head-to-head of four upper-arm capillary devices (incl. TAP Micro Select) versus fingerstick and venous: experience and performance varied by device with none clearly superior, while analyte correlations with venous were similar across all.
Evaluation of a Simplified Upper-Arm Device for Vacuum-Assisted Collection of Capillary BloodSchaff et al. · Diagnostics · 2025 · Open accessA vacuum-assisted upper-arm device collected a mean 538 µL and met the volume target in 85.5% of cases; 17 of 19 analytes met CLIA agreement with venous, with pain lower than fingerstick.Open-access full text (PDF)
Comparison of capillary and venous plasma lipidomes: validation of self-collected blood for plasma lipidomicsHameed et al. · J. Lipid Research · 2025 · Open accessPlasma lipidomes from self-collected upper-arm capillary blood were statistically indistinguishable from paired venous plasma (most classes r=0.95–0.99) (validating at-home capillary self-collection for lipidomics).Open-access full text (PDF)
PediatricsYourBio
Transdermal blood sampling for C-peptide is a minimally invasive, reliable alternative to venous sampling in children and adults with type 1 diabetesBesser et al. · Diabetes Care · 2024 · Open accessIn 91 children and adults, capillary C-peptide taken with the TAP device matched venous sampling with 100% sensitivity and specificity for a clinically relevant level (≥200 pmol/L; r = 0.996). 63% preferred it to a needle against 7% who preferred the needle, and same-day bruising was 5.5% versus 34.8% after a venous draw.Open-access full text (PDF)
Feasibility, acceptability and safety of a device for self-collecting capillary blood in clinical trialsDasari et al. · PLOS ONE · 2024 · Open accessIn at-home and trial settings, a wet capillary device reliably collected a median ~450 µL with a 4.4% failure rate; 88% of adults preferred self-collection over venipuncture, with lower pain.Open-access full text (PDF)
YourBio
Maximizing microsampling: measurement of comprehensive metabolic and lipid panels using a novel capillary blood collection deviceCollier et al. · The Journal of Applied Laboratory Medicine · 2023 · PaywalledTAP II capillary serum (both professionally collected and self-collected) correlated with venous serum at R > 0.9 for eight analytes including ALT, AST, cholesterol, HDL and triglycerides. Creatinine correlated acceptably but carried a consistent negative bias, and carbon dioxide, potassium and albumin did not reach acceptable agreement: the useful reading is that the panel has to be validated, not the device alone.
Capillary blood stability and analytical accuracy of 12 analytes stored in MicrotainersFontaine & Saez · Practical Laboratory Medicine · 2023 · Open accessFingerstick blood self-collected into BD Microtainer tubes and posted at ambient temperature for 24 h agreed acceptably with paired serum for 11 of 12 analytes (HbA1c, lipids, creatinine, urea, urate, liver enzymes and total protein) with only AST falling outside limits.Open-access full text (PDF)
PediatricsYourBio
Durability of anti-spike antibodies in infants after maternal COVID-19 vaccination or natural infectionShook, Edlow et al. · JAMA · 2022 · Open accessThe paper records that the TAP II devices used for the infant draws were provided by YourBio Health, and that capillary serum was collected from babies as young as two months (the smallest patients sampled, without a heel prick or a venepuncture).Open-access full text (PDF)
YourBio
Remote self-collection of upper-arm capillary blood for autoantibody analysis in immune-mediated rheumatic diseasesZarbl et al. · RMD Open · 2022 · Open accessPatients self-collected upper-arm capillary blood with press-activated devices (incl. TAP II); autoantibody and CRP results agreed with venous (r≥0.98), were rated less painful, and 98.6% got enough blood within two attempts.Open-access full text (PDF)
Accuracy and tolerability of capillary self-sampling for inflammation and autoantibodies in rheumatoid arthritis: a randomized controlled trialKnitza et al. · Arthritis Research & Therapy · 2022 · Open accessCapillary self-sampling gave CRP and autoantibody values nearly identical to venous (ICC 0.97–0.998), was less painful, and the upper-arm route drew far higher acceptance and willingness to sample at home.Open-access full text (PDF)
YourBio
Quantitative metabolomics comparison of traditional blood draws and TAP capillary blood collectionCatala et al. · Metabolomics · 2018 · PaywalledMetabolomics of TAP capillary blood matched venous draws for most metabolites (amino acids, bile acids, acyl-carnitines r≥0.95); a small redox/energy subset differed with collection dynamics.

External links open an open-access full text where one exists, otherwise the publisher or PubMed record. These citations describe the published evidence for the collection formats and devices (not claims about specific Humans Nexus assays, which are validated per analyte and per laboratory).

Give pediatrics its data back.

Somewhere a parent is postponing a blood test their child needs. Build the programme that ends that (trials, chronic care or family health).