ORAcollect.
Saliva DNA, even when spitting isn’t an option.
ORAcollect is DNA Genotek’s sponge-based saliva device: an absorbent sponge in the cap collects oral fluid or swabs the inside of the mouth, and closing it releases a stabilising buffer that preserves the DNA at the point of collection, a median 2.6 µg by the maker’s figure, nearly four times a buccal swab, stable at ambient temperature for months. The gentler route for children, infants and anyone who cannot spit on cue, at home or at the point of care. Curated and supplied on the Humans Nexus platform; DNA Genotek is the manufacturer.
ORAcollect assisted saliva collection.
ORAcollect is a saliva microsampling device from DNA Genotek that collects with an integrated sponge rather than a spit funnel: the sponge in the cap absorbs oral fluid or swabs the inside of the mouth, and closing the device releases a stabilising buffer that mixes with the sample and preserves the DNA at the moment of collection. Per the manufacturer, this makes collection easy for infants, young children and anyone who struggles to produce saliva on demand, and the ambient-stable tube travels at room temperature and reaches the laboratory intact. Humans Nexus curates and supplies the device on its platform and assembles the clinical-grade kit around it; DNA Genotek is the legal manufacturer.
In the maker’s own figures for the Dx configuration, OCD-100, ORAcollect yields a median 2.6 µg of DNA against 0.7 µg for a buccal swab, holds the specimen stable at ambient temperature for months, and in the maker’s user study 99.5% of specimens contained sufficient DNA and every extracted sample reached a 99.7% call rate on a genotyping test; it is FDA-cleared for in vitro diagnostic use, for prescription and over-the-counter collection. Device-level regulatory status is held by DNA Genotek.
A gentler collection,
the same stabilised DNA.
Not everyone can spit into a funnel; infants, young children and many patients simply cannot on cue. ORAcollect is designed by the manufacturer to collect saliva with a sponge instead, so the same ambient-stable, buffer-locked DNA can be captured from people a spit device can’t reach, and travel by ordinary tracked post to the lab.
What the record shows. Saliva collected on ORAcollect swabs and sequenced for BRCA1 and BRCA2 gave 98% variant-calling concordance with blood, every sample yielding enough DNA for library preparation (International Journal of Genomics, 2016); the paper names the device in its methods.
Which saliva device?
Two DNA Genotek saliva devices, one decision: how the sample is given. ORAcollect uses a sponge in the cap to collect or swab, the gentler route for children, infants and anyone who cannot spit on cue. ORAgene takes a full spit through a funnel, the higher-yield option for adult self-collection.
| ORAcollect | ORAgene | |
|---|---|---|
| Collection | Sponge in the cap, collect or swab | Spit into the funnel |
| Best suited to | Children, infants & assisted collection | Adult self-collection |
| Typical volume | Smaller, targeted | Larger, a full saliva sample |
| DNA yield | Ready DNA for routine molecular tests | High-molecular-weight DNA, sequencing & biobanking |
| Stabilisation | Liquid buffer, ambient for months, per the maker | Liquid buffer, ambient for years, per the maker |
| Lab handling | Standard robotics, no tip-cutting | Standard robotics, no tip-cutting |
Both share DNA Genotek’s liquid stabilisation, a bacteriostatic buffer that holds DNA at room temperature, for months with ORAcollect and for years with ORAgene by the maker’s own pages, and both run on standard laboratory robotics without tip-cutting. The right device depends on who collects and what the assay needs; method validation runs per assay before patient-facing reporting. See ORAgene →
Collect. Stabilise. Return.
The sponge in the cap absorbs saliva or swabs the inside of the mouth at home, easy for children and assisted collection.
Closing the device releases the stabilising buffer, which mixes with the sample and locks the DNA at ambient temperature.
Ships by tracked return with no cold chain; the lab processes the stabilised sample.
Assembled into a kit.
The ORAcollect device is curated onto the platform and assembled into a regulated Humans Nexus collection kit: device, stabilising buffer, tamper-evident return packaging and app-guided instructions, under its own UDI.
For pediatrics and point-of-care.
Good to know.
What does ORAcollect collect?
Saliva. A sponge in the cap absorbs oral fluid or swabs the inside of the mouth, and the sample is stabilised at collection for oral-fluid DNA, the gentler route for children and assisted collection.
How is it different from ORAgene?
ORAcollect uses a sponge to collect or swab, which suits children, infants and anyone who cannot spit; ORAgene is a spit device for adult self-collection and a larger, higher-yield sample. Both are DNA Genotek saliva devices sharing the same liquid stabilisation.
How much DNA does ORAcollect yield?
A median 2.6 µg per the maker, against 0.7 µg for a buccal swab; in the maker’s user study 99.5% of specimens contained sufficient DNA.
How long is the sample stable at room temperature?
Months, per the maker’s page for the Dx configuration.
Does it need cold chain?
No. Per the manufacturer, the device stabilises the sample at collection, so the ambient-stable tube is designed to ship at room temperature by standard tracked return.
Is ORAcollect CE marked?
The maker states FDA clearance for the Dx configuration; no CE statement appears on the maker’s pages, so Humans Nexus claims none. Device-level regulatory status is held by DNA Genotek, and each assay is validated in an ISO 15189-accredited laboratory before a patient-facing result.
Who is the manufacturer?
DNA Genotek makes the device. Humans Nexus curates and supplies it on the platform and assembles the clinical-grade kit around it. Method validation runs per assay before patient-facing reporting.
Library ORAcollect
Evaluation of Saliva as a Matrix for RT-PCR Analysis and Two Rapid Antigen Tests for the Detection of SARS-CoV-2
Read in the LibraryValidation of saliva as an alternative specimen for detecting hereditary breast-cancer mutations by next-generation sequencing
Read in the LibraryAssociation of Amelogenin with High Caries Experience in Indian Children
Read in the Library
One free account opens every finding in the OpenSampling Library. The same account signs you in to Pulse.
These citations describe the published evidence for the collection formats and devices, not claims about specific Humans Nexus assays, which are validated per analyte and per laboratory.
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